Principal Investigator: Wei-Chuan ShihAssociate Professor with tenure (effective 9/2015)
Department of Electrical and Computer Engineering, Biomedical Engineering, and Chemistry
University of Houston
Email: email@example.com / Phone: 713-743-4454
Eng. Bldg. 1 N308, Houston Texas 77204
Biosketch (CV)Wei-Chuan Shih earned his BS, MS, and Ph.D. from National Taiwan U, National Chiao Tung U, and Massachusetts Institute of Technology, respectively. His Ph.D. work was conducted at MIT Spectroscopy Laboratory/NIH Laser Biomedical Research Center under late laser physicist Dr. Michael S. Feld, studying novel optical spectroscopy techniques for non-invasive chemical/biomedical sensing and disease diagnosis. He also worked extensively on MEMS design and nanofabrication at MIT Mechanical Engineering under Drs. George Barbastathis and Sang-Gook Kim. Prior to joining the U. of Houston, he was a Schlumberger research fellow, studying optical analysis of hydrocarbon and offshore oil spill monitoring.
Dr. Shih is tenured Associate Professor of Electrical & Computer Engineering, Biomedical Engineering, Materials Science & Engineering and Chemistry at the U. of Houston. He was a MIT Martin Fellow of Sustainability, and received NSF CAREER Award in Biophotonics, inaugural NASA Early CAREER Faculty Award, UH Award for Excellence in Research and Scholarship, and UH Cullen College of Engineering Faculty Research Excellence Award. Besides NSF and NASA, his research is also supported by NIH, DoI, and GoMRI, with a past 5-year total over US$3.5M.
Dr. Shih has published more than 70 articles in books, journals and conference proceedings. He has published 40 peer-reviewed journal papers, and is Corresponding Author in 33 of them. He has more than 12 patents, one of which has been licensed. His scholarly papers appear in field-leading peer-reviewed journals such as ACS Nano Letters, Applied Materials & Interfaces, Analytical Chemistry; Wiley Advanced Materials, J. Biophotonics, RSC Nanoscale, J. of Materials Chemistry, Analysts, Advances; OSA Optics Express, Biomedical Optics Express, Optical Materials Express, Optics Letters, Applied Optics; SPIE J. of Biomedical Optics, SAS Applied Spectroscopy, and IEEE/ASME J. MEMS. His research has been featured on OSA Optics & Photonics News (OPN), CNBC, Forbes, ScienceDaily, Phys.org, SpectroscopyNOW, Houston PBS, UH Moment and numerous other media outlets. Dr. Shih has delivered seminars at famed institutions such as MIT, Columbia, Duke, Rice, NC State, U Minnesota, UT Health, UC Davis, TAMU, Johns Hopkins, U Iowa, Vanderbilt, RPI, NCTU, NTU, CUHK, HKU, NIH, Schlumberger, Halliburton and etc. He has also deliver invited talks at conferences such as SPIE Photonics West, ACS meetings, IEEE NANOMED, PittCon, SciX/FACSS, META, and etc. He has actively engaged in serving the scientific community by the following participation: IEEE NANOMED (general program co-chair), IEEE Optics MEMS & Nanophotonics (technical committee member), SPIE Photonics West and SPIE Translational Biophotonics (technical committee member), and numerous session chairing.
Honors2015 Faculty Research Excellence Award, CCE, University of Houston
2013 Award for Excellence in Research and Scholarship (university level), University of Houston
2012 NSF CAREER Award
2012 NASA Early CAREER Faculty Award (inaugural)
2011 NIH study section panelist (2011-present)
2011 Best Poster award, ECI: Advances in Optics for Biotechnology, Medicine and Surgery
2008 Best paper award, Schlumberger NAM REMS Reservoir Symposium
2007 Schlumberger Postdoctoral Fellow (Schlumberger-Doll Research)
2005 MIT Martin Fellow
1999 Phi Tau Phi Scholastic Honor Society
Honors of group members2014 Best PhD dissertation award (Ji Qi), Cullen College of Engineering, U Houston
2014 Best poster award (Ji Qi), Graduate Research Conference, U Houston
2013 Best oral presentation award (Jingting Li), Graduate Research Conference, U Houston
2013 Best poster award (Szu-Te Lin), Graduate Research Conference, U Houston
2012 Best poster award (Ji Qi), Graduate Research Conference, U Houston
TeachingBiophotonics (ECE6339) (Spring ’14, ’15, Initiated)
Optical Imaging and Spectroscopy (ECE 6397) (Spring '11, ’12, ’13)
Signals and Systems / Electrical Engineering Analysis (ECE 3337) (Fall '10, '11,’12, ’13, ’14)
Optical and Ultrasound Imaging (ECE 6338) (Spring '10)
Digital Signal Processing (ECE 6342) (Fall '09)
Dr. Greggy Santos, Dr. Oussama Zenasni, Dr. Rui Lu, Dr. Suyan Qiu, Jingting Li, Fusheng Zhao, Yulung Sung, MD Masud Arnob, Hoang Nguyen, Zhenyu Hu (UG)
Postdocs: Dr. Gauri Bhavi, Dr. Jianbo Zeng, Dr. Ming Li, Dr. Po Sun, Dr. Jinwei Li
Students: Dr. Mufaddal Gheewala (Co-Advised, now at Intel), Dr. Ji Qi (Optical Physicist at Schlumberger), Dr. Lanchao Liu (Co-Advised ), Dr. Pratik Motwani (Co-Advised), Jing Lu, Szu-Te Lin, Cesar Figueroa (Provost Undergraduate Research Scholar) (U. Michigan EECS PhD program) ,Emery Annis (Provost Undergraduate Research Scholar), Shivali Narang (Biomedical Eng. UG), Gustavo Acevedo (Provost UG Fellow, now at Schlumberger)
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Book Chapters and Magazine Articles1 Wei-Chuan Shih, “Hybrid fabrication makes better plasmonic nanostructures for SERS,” Photonics Spectra, August, 2013.
2 Wei-Chuan Shih, Kate L Bechtel, Michael S Feld, Mark A Arnold and Gary W Small, “Introduction to Spectroscopy-Based Non-invasive Glucose Sensing,” In Vivo Glucose Sensing, Editors: D. Cunningham and J. A. Stenken (Wiley 2009).
3 Wei-Chuan Shih, Kate L Bechtel and Michael S Feld, “Non-invasive Glucose Sensing with Raman spectroscopy,” In Vivo Glucose Sensing, Editors: D. Cunningham and J. A. Stenken (Wiley 2009).
4 Wei-Chuan Shih, Kate L Bechtel, Michael S Feld, “Quantitative Biological Raman Spectroscopy,” in Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues, Editor: Valery V. Tuchin (Taylor & Francis 2008).
Peer-reviewed Journal Publications(*: Corresponding author)
1 Jae Won Jeong, Md Masud Parvez Arnob, Kwang-Min Baek, Seung-Yong Lee, Wei-Chuan Shih, and Yeon Sik Jung, Three-dimensional Cross-point Plasmonic Nano-architectures Containing Dense and Regular Hot Spots for Surface-Enhanced Raman Spectroscopy Analysis [Link] Advanced Materials, 2016. (DOI: 10.1002/adma.201602603)
2 WC Shih*, G Santos, F Zhao, O Zenasni, and M Arnob, Simultaneous chemical and refractive index sensing in the 1-2.5 um near-infrared wavelength range on nanoporous gold disks [Link]
Nano Letters 2016.
3 G Santos, F Ferrara, F Zhao, DF Rodrigues, and WC Shih*
Photo thermal inactivation of heat-resistant bacteria on nanoporous gold disk arrays [Link]
Optical Materials Express 6(4): 1217-1229 2016.
1 Jingting Li, Yong Du, Ji Qi, Ravikumar Sneha, Anthony Chang, Chandra Mohan, and Wei-Chuan Shih*
Raman spectroscopy as a diagnostic tool for monitoring acute nephritis (In Press)
Journal of Biophotonics 2015.
3 Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Chandra Mohan, and Wei-Chuan Shih*
Reagent- and separation-free measurements of urine creatinine concentration by stamping surface-enhanced Raman scattering (S-SERS) [Link]
Biomedical Optics Express 6(3): 849-858 2015.
4 Greggy M Santos, Fusheng Zhao, Jianbo Zeng, Ming Li, and Wei-Chuan Shih*
Label-free, zeptomole cancer biomarker detection by surface-enhanced fluorescence on nano porous gold disk plasmonic nano particles [Link]
Journal of Biophotonics 2015 (Published 2/2015).
5 O Khantamat, CH Li, F Yu, AC Jamison, WC Shih, C Cai and TR Lee
Gold nanoshell-decoraed silicone surfaces for the NIR photo thermal destruction of the pathogenic bacterium E. faceless
ACS Applied Materials & Interfaces 2015 (Accepted 2/1//2015).
6 Wei-Chuan Shih*, Kate L Bechtel, and Mihailo Rebec
Non-invasive glucose sensing by transcutaneous Raman spectroscopy [Link]
Journal of Biomedical Optics 20(5): 051036 2015.
7 Ji Qi, Pratik Motwani, Jianbo Zeng, John C Wolfe, and Wei-Chuan Shih*
Morphological, plasmonic, and SERS characterization of DC-sputtered gold nanoislands [Link]
Biomedical Spectroscopy and Imaging 4(1): 95-103, 2015 (Accepted 12/23/2014) [PDF].
8 Fusheng Zhao, Jianbo Zeng, Greggy M Santos, and Wei-Chuan Shih*
In situ patterning of hierarchical nanoporous gold structures by in-plane dealloying [Link]
Materials Science and Engineering B 194: 34-40, 2015 (Accepted 12/7/2014) [PDF].
9 Wei-Chuan Shih*
A study of constrained regularization and its performance on non-invasive glucose sensing using Raman spectroscopy [Link]
Journal of Innovative Optical Health Sciences 2015 (Accepted 11/24/2014) (DOI: 10.1142/S1793545815500224) [PDF].
10 Jianbo Zeng, Fusheng Zhao, Ming Li, Chien-Hung Li, T. Randall Lee, and Wei-Chuan Shih*
Morphological control and plasmonic tuning of nanoporous gold nanoparticles by surface modifications [Link]
Journal of Materials Chemistry C 3(2): 247-252 2015 (Published as Adv. Art. 12/1/2014). [PDF]
1 Ji Qi, Kate L Bechtel, and Wei-Chuan Shih*
Automated image curvature assessment and correction for high-throughput Raman spectroscopy and microscopy [Link]
Biomedical Spectroscopy and Imaging 3(4): 359-368, 2014. [PDF]
2 Md Masud Parvez Arnob, Fusheng Zhao, Jianbo Zeng, and Wei-Chuan Shih*
Laser rapid thermal annealing enables tunable plasmonics in nanoporous gold nanoparticles [Link]
Nanoscale 6(21):12470-12475, 2014. [PDF]
3 Jianbo Zeng, Fusheng Zhao, Chien-Hung Li, Yifei Li, Yan Yao, T. Randall Lee, and Wei-Chuan Shih*
Internal and external morphology-dependent plasmonic properties in nanoporous gold disks [Link]
RSC Advances 4, 36682-36688, 2014. [PDF]
4 Narendran Sudheendran, Ji Qi, Eric D. Young, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock, Kirill V. Larin, Wei-Chuan Shih*
High throughput Raman spectral imaging complements optical coherence tomography for tumor boundary detection [Link]
Laser Physics Letters 11:105602, 2014 [PDF]
5 Ming Li, Fusheng Zhao, Jianbo Zeng, Ji Qi, Jing Lu, and Wei-Chuan Shih*
Microfluidic surface-enhanced Raman scattering (SERS) sensor with monolithically integrated nanoporous gold disk (NPGD) arrays for rapid and label-free biomolecular detection [Link]
Journal of Biomedical Optics 19(11): 111611 2014 [PDF]
7 Ji Qi, Jianbo Zeng, Fusheng Zhao, Steven Hsesheng Lin, Balakrishnan Raja, Ulrich Strych, Richard C. Willson, and Wei-Chuan Shih*
Label-free, in situ SERS monitoring of individual DNA hybridization in microfluidics [Link]
Nanoscale 6, 8521-8526, 2014 [PDF]
8 Jing Yang, Xuebin Tan, Wei-Chuan Shih, and Mark Cheng
A sandwich substrate for ultrasensitive SERS spectroscopic detection of folic acid / methotrexate [Link]
Biomedical Microdevices 16(5), 673-679, 2014 [PDF]
9 Fusheng Zhao, Jianbo Zeng, Md Masud Parvez Arnob, Po Sun, Ji Qi, Pratik Motwani, Mufaddal Gheewala, Chien-Hung Li, Andrew Paterson, Uli Strych, Balakrishnan Raja, Richard C. Willson, John C. Wolfe, T. Randall Lee, and Wei-Chuan Shih*
Monolithic nanoporous gold disks with large specific surface area, tunable plasmon resonance, and high-density, internal plasmonic hot-spots [Link]
Nanoscale 6, 8199-8207, 2014 [PDF]
10 Greggy M. Santos, Fusheng Zhao, Jianbo Zeng, and Wei-Chuan Shih*
Characterization of nanoporous gold disks for photothermal light harvesting and light-gated molecular release [Link]
Nanoscale 6(11), 5718-5724, 2014 [PDF]
12 Peter Liu, Ji Qi, Wei-Chuan Shih*, and Kirill Larin*
Improvement of tissue analysis and classification using Optical Coherence Tomography combined with Raman spectroscopy [Link]
Journal of Innovative Optical Health Sciences 8(2), 1550006, 2014 [PDF]
13 Ming Li, Jing Lu, Ji Qi, Fusheng Zhao, Jianbo Zeng, Jorn Chi-Chung Yu, and Wei-Chuan Shih*
Stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging [Link]
Journal of Biomedical Optics 19(5): 050501, 2014. [PDF]
1 Ji Qi, Pratik Motwani, Mufaddal Gheewala, Christopher Brennan, John C. Wolfe, and Wei-Chuan Shih*
Surface-enhanced Raman spectroscopy using monolithic nanoporous gold disk substrates [Link]
Nanoscale 5: 4105-4109, 2013 [PDF]
1 A Ballard Andrews, Wei-Chuan Shih, Oliver C Mullins and N. Koyo
Molecular size determination of coal-derived asphaltene by fluorescence correlation spectroscopy [Link]
Applied Spectroscopy 65(12):1348-1356, 2011 [PDF]
3 Wei-Chuan Shih, Kate L Bechtel and Michael S Feld
Intrinsic Raman spectroscopy for quantitative biological spectroscopy Part I: Theory and simulations [Link]
Optics Express 16(17): 12726-12736, 2008 [PDF]
4 Kate L Bechtel, Wei-Chuan Shih and Michael S Feld
Intrinsic Raman spectroscopy for quantitative biological spectroscopy Part II: Experimental applications [Link]
Optics Express 16(17): 12737-12745, 2008 [PDF]
6 Obrad Scepanovic, Kate L Bechtel, Abigail S Haka, Wei-Chuan Shih, Tae-Woong Koo, Andrew J Berger, and Michael S Feld
Determination of uncertainty in parameters extracted from single spectroscopic measurements [Link]
Journal of Biomedical Optics 12(6), 064012, 2007 [PDF]
7 Wei-Chuan Shih*, Sang-Gook Kim and George Barbastathis
High resolution electrostatic analog tunable grating with a single-mask fabrication process [Link]
IEEE/ASME JMEMS, vol. 15, no. 4, pp. 763-769, 2006 [PDF]
8 AMK Enejder, TG Scecina, J Oh, M Hunter, WC Shih, S Sasic, GL Horowitz, and MS Feld
Raman spectroscopy for non-invasive glucose measurements [Link]
Journal of Biomedical Optics 10(3), 031114, 2005 [PDF]
Peer-reviewed Conference Full-length Article (12)1 “Flexible optitrode for localized light delivery and electrical recording,” SPIE Photonics West, San Francisco CA, Jan 2013.
2 “Monolithic porous gold nanostructures as surface-enhanced Raman spectroscopy substrates for molecular and biosensing,” SPIE Photonics West, San Francisco CA, Jan 2013.
3 “Sparse-sampling parallel Raman/SERS microspectroscopy for high-throughput molecular analysis of micro and nanoparticles,” SPIE Photonics West, San Francisco CA, Jan 2013.
4 “High throughput Raman and surface-enhanced Raman microscopy,” SPIE Photonics West, San Francisco CA, Jan 2012.
5 “Integrated multi-sensing optrode for neural stimulation and recording,” SPIE Photonics West, San Francisco CA, Jan 2012.
6 "Oil spill sensor using multispectral infrared imaging via l1 minimization," ICASSP, Prague, May, 2011.
7 “Offshore stand-off oil spill monitoring using passive optical imaging,” Proc. SPIE 7312, 73120V, 2009.
8 “Intrinsic Raman spectroscopy improves analyte concentration measurements in turbid media,” Biomedical Optics Topical Meeting by Optical Society of America, Fort Lauderdale, FL, Mar, 2006.
9 “Optical diversity by nanoscale actuation,” IEEE NANO, San Francisco CA 2003.
10 “Analog tunable gratings with nanometer resolution,” Solid-state Sensor and Actuator Workshop, Hilton Head SC, 2002.
11 “Electrostatic and piezoelectric analog tunable diffractive gratings,” Lasers and Electro-Optics (CLEO), Long Beach CA 2002.
12 “Analog tunable diffractive grating with milliradian resolution,” Optical Fiber Communication Conference (OFC), Anaheim CA 2002.
2 62004131, Nanoporous gold and silver nanoparticles and substrates for biomolecular sensing (Provisional application); Inventor: Wei-Chuan Shih and Richard C Willson; Assignee: U. Houston
3 61985984, Method of stamping surface-enhanced Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging (Provisional application); Inventor: Wei-Chuan Shih and Ming Li; Assignee: U. Houston
4 61827192, Integrated thin-film optrode (Provisional application); Inventor: John C Wolfe, Mufaddal Gheewala, Wei-Chuan Shih; Assignee: U. Houston
5 13/796,201 Nanoporous gold nanoparticles as high-payload molecular cargo for cancer treatment and ultrahigh surface-to-volume sensor applications (Patent pending); Inventor: Wei-Chuan Shih; Assignee: U. Houston
6 US8902421 Method and system for Raman microspectroscopy (Patent allowance obtained); Inventors: Wei-Chuan Shih; Assignee: U. Houston
7 US8661663 Method for manufacturing a multimodal neural probe; Inventors: John C Wolfe and Wei-Chuan Shih; Assignee: U. Houston
8 US6975459 Micro-actuated adaptive diffractive composites; Inventors: G Barbastathis, SG Kim, Wei-Chuan Shih, CW Wong, YB Jeon; Assignee: MIT
9 US8124931 Method and apparatus for oil spill detection; Inventors: AB Andrews, Wei-Chuan Shih, M Clayton, OC Mullins; Assignee: Schlumberger Technology Corporation
10 US8362429 Method and apparatus for oil spill detection; Inventors: AB Andrews, Wei-Chuan Shih, M Clayton, OC Mullins; Assignee: Schlumberger Technology Corporation
11 US 8355767 Raman spectroscopy for non-invasive glucose measurements; Inventors: M. Hunter, A. Enejder, T. Scecina, M. Feld, Wei-Chuan Shih ; Assignee: MIT
PhD student openings and postdoc positions:
Required skills:I am looking for highly motivated PhD students and Postdocs who aspire to become a professor or have a research career. I would be happy to talk to you if you worked in the specific fields and have the specific skills listed below.
Specific fields of interest are: Surface-enhanced Raman scattering, Plasmonic sensors, Plasmonic light emitters, Plasmonic waveguides, Plasmonic solar harvesting, and Plasmonic catalysis.
Specific skills I am looking for within these fields are: Innovative optical and spectroscopic instrumentation, Microfluidics, Nanofabrication, Organic or Silicon photovoltaic, FDTD, Bio-conjugation, Surface chemistry and functionalization.